Guy Quigley was born in Ireland and hails from a third-generation Irish thespian and musical family. He and his wife, Wendy, relocated to the United States in 1983. They have three children and five grandchildren.

In writing his novel The Rebel Son, Guy drew heavily on his life experiences in Africa, which include ownership of a 40,000-acre cattle ranch in Zambia and a real estate company in Rhodesia (Zimbabwe). He was forced to cease operations due to the explosive Liberation War.

In 1989 he formed The Quigley Corporation, introducing Cold-Eeze® to the US marketplace. He is a Co-Executive Producer of a movie entitled Magic Boys, due for release in 2011.